Digital Publications
SPOTLIGHT ON IMMUNOTHERAPY
Immunotherapy is revolutionizing cancer treatment and is the most promising bet we have at a long sought for cancer cure. By awakening and priming the immune system to fight cancer, such strategies have achieved impressive clinical successes. In this article, I briefly describe the research advances for some of the most impactful approaches to cancer immunotherapy as well as the opportunities and challenges in their broad implementation for cancer treatment.
Immunotherapy is revolutionizing cancer treatment and is the most promising bet we have at a long sought for cancer cure. By awakening and priming the immune system to fight cancer, such strategies have achieved impressive clinical successes. In this article, I briefly describe the research advances for some of the most impactful approaches to cancer immunotherapy as well as the opportunities and challenges in their broad implementation for cancer treatment.
NEXT GENERATION BIOLOGY METHODS
Dear reader, I wrote this article to briefly introduce you to ten of the most influential methods that are reshaping biology research and biomedical applications. Each section includes a short description and notable uses of the respective method.
Dear reader, I wrote this article to briefly introduce you to ten of the most influential methods that are reshaping biology research and biomedical applications. Each section includes a short description and notable uses of the respective method.
GENOME ALTERATIONS AND BRAIN FUNCTION
Normal cellular functions and organism survival depend on a high degree of genetic stability. Recent evidence, however, is revealing that the genome is subject to complex sequence alterations. In this article, I describe recent findings suggesting that genomic alterations, mediated by DNA double-strand break (DSB) formation and repair, play an important role in brain physiology, aging, cancer, and neurodegenerative disorders.
Normal cellular functions and organism survival depend on a high degree of genetic stability. Recent evidence, however, is revealing that the genome is subject to complex sequence alterations. In this article, I describe recent findings suggesting that genomic alterations, mediated by DNA double-strand break (DSB) formation and repair, play an important role in brain physiology, aging, cancer, and neurodegenerative disorders.
VIRAL VECTORS IN GENE THERAPY
Adeno-associated virus (AAV) vectors are the leading gene delivery platform spearheading multiple preclinical and clinical successes involving gene replacement, silencing and editing therapies. Their biology reveals a complex network of interactions with host cell factors underlying their life cycle and capacity to function as gene delivery vehicles. Have a look at this brief article I wrote on the topic for an overview.
Adeno-associated virus (AAV) vectors are the leading gene delivery platform spearheading multiple preclinical and clinical successes involving gene replacement, silencing and editing therapies. Their biology reveals a complex network of interactions with host cell factors underlying their life cycle and capacity to function as gene delivery vehicles. Have a look at this brief article I wrote on the topic for an overview.
MITOCHONDRIA AND COGNITION
Adult hippocampal neurogenesis reinforces cognitive processes including learning and memory and the encoding of temporal information. Known as the powerhouse of the eukaryotic cell, mitochondria have emerged in recent years as key regulators of stem cell function. In this article, I describe how mitochondria regulate NSC function and cognition, and how they may be targeted with stem cell-based therapies or other interventions to improve cognitive function.
Adult hippocampal neurogenesis reinforces cognitive processes including learning and memory and the encoding of temporal information. Known as the powerhouse of the eukaryotic cell, mitochondria have emerged in recent years as key regulators of stem cell function. In this article, I describe how mitochondria regulate NSC function and cognition, and how they may be targeted with stem cell-based therapies or other interventions to improve cognitive function.
THE HUMAN GENOME
How much do you remember about the structure of DNA or the human genome? Have a look over this brief article I wrote on the topic, refresh your knowledge and learn some unexpected new facts about the human genome.
How much do you remember about the structure of DNA or the human genome? Have a look over this brief article I wrote on the topic, refresh your knowledge and learn some unexpected new facts about the human genome.
CRISPR GENETICS
CRISPR-Cas systems evolved in bacteria and archaea, and provide for adaptive immunity against foreign DNA, such as that from invading viruses. Modified CRISPR-Cas systems have dramatically transformed our ability to edit the genome paving the way toward targeted therapeutic interventions. In this article, I reviewed CRISPR targeting methodology, prospective engineering advances, and potential applications ranging from basic science to the clinic.
CRISPR-Cas systems evolved in bacteria and archaea, and provide for adaptive immunity against foreign DNA, such as that from invading viruses. Modified CRISPR-Cas systems have dramatically transformed our ability to edit the genome paving the way toward targeted therapeutic interventions. In this article, I reviewed CRISPR targeting methodology, prospective engineering advances, and potential applications ranging from basic science to the clinic.
English Genetic Engineering with CRISPR
German Genetik Mit CRISPR Gestalten
A web interactive digital publication offering insights into the role of Mapk and mToR in protein synthesis and cancer formation.
Tldr: The Erk Mapk (mitogen-activated protein kinase) pathway is a conserved regulator of cell and tissue growth. The Mapk-activated protein kinases (Mapkapks) are important effectors mediating Mapk regulation of translation and cellular metabolism. Mounting evidence implicates Mapkapk proteins together with mToR in growth regulation and cancer progression. However, the extent of their crosstalk with mToR and their functionality in different tissues and cancer types are incompletely understood and subject to active investigation.
Our diet can change the structure and functionality of our intestines, and have a long-term impact on our metabolism. A study conducted by a team of researchers at the Carnegie Institution for Science supports this view. But what does this mean?
An article published in the journal of Current Biology states that our genes are the main culprits for our aging-associated breakdown. Their study suggests that certain processes useful early on in life, become damaging in later life causing age-related diseases. Here I wrote a minireview that briefly discusses this finding.
English Genes Drive Aging
By promoting cellular recycling we might be able to significantly prolong our lifespan. A study conducted by researchers at Sanford Burnham Prebys Medical Institute points in this direction. They have undertaken the first ever comprehensive analysis of this process in a living animal during aging.
English Autophagy and Aging
German Autophagie und Altern
Valuable knowledge and beautiful design are of not much use if we cannot share them and collaborate with others. To achieve this on our most extensive network, the internet, one generally needs to build a website. But what is actually a website? Each website page is composed of a framework written in HTML which describes the main elements on that page. One level up, each page also has a corresponding CSS sheet that determines how all the HTML-defined elements appear on the page. CSS-defined properties include size, color, hover behavior, simple animations, etc. To nicely illustrate this structure and functionality, my article offers not only a brief introduction of relevant concepts but also my complete code for a mockup site.